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Page 1
Precision medicine for human cancers with Notch signaling dysregulation (Review).
Katoh M, Katoh M. Katoh M, et al. Int J Mol Med. 2020 Feb;45(2):279-297. doi: 10.3892/ijmm.2019.4418. Epub 2019 Dec 4. Int J Mol Med. 2020. PMID: 31894255 Free PMC article. Review.
However, Notch signaling is inactivated in small-cell lung cancer and squamous cell carcinomas. Loss-of-function NOTCH1 mutations are early events during esophageal tumorigenesis, whereas gain-of-function NOTCH1 mutations are late events during T-cell leukemo …
However, Notch signaling is inactivated in small-cell lung cancer and squamous cell carcinomas. Loss-of-function NOTCH1 mutati …
CDK5 positively regulates Notch1 signaling in pancreatic cancer cells by phosphorylation.
Chu Q, Wang L, Zhang J, Wang W, Wang Y. Chu Q, et al. Cancer Med. 2021 Jun;10(11):3689-3699. doi: 10.1002/cam4.3916. Epub 2021 May 7. Cancer Med. 2021. PMID: 33960694 Free PMC article.
The marked overexpression of cyclin-dependent kinase 5 (CDK5) or Notch1 receptor, which plays critical roles in pancreatic ductal adenocarcinoma (PDAC) development, has been detected in numerous PDAC cell lines and tissues. ...Herein, we identified a physical …
The marked overexpression of cyclin-dependent kinase 5 (CDK5) or Notch1 receptor, which plays critical roles in pancreatic …
Hypoxia potentiates gemcitabine-induced stemness in pancreatic cancer cells through AKT/Notch1 signaling.
Zhang Z, Han H, Rong Y, Zhu K, Zhu Z, Tang Z, Xiong C, Tao J. Zhang Z, et al. J Exp Clin Cancer Res. 2018 Nov 28;37(1):291. doi: 10.1186/s13046-018-0972-3. J Exp Clin Cancer Res. 2018. PMID: 30486896 Free PMC article.
BACKGROUND: Profound chemoresistance remains an intractable obstacle in pancreatic cancer treatment. Pancreatic cancer stem cells (CSCs) and the ubiquitous hypoxic niche have been proposed to account for drug resistance. ...This study investigated whet …
BACKGROUND: Profound chemoresistance remains an intractable obstacle in pancreatic cancer treatment. Pancreatic canc …
GAS41 mediates proliferation and GEM chemoresistance via H2A.Z.2 and Notch1 in pancreatic cancer.
Han S, Cao C, Liu R, Yuan Y, Pan L, Xu M, Hu C, Zhang X, Li M, Zhang X. Han S, et al. Cell Oncol (Dordr). 2022 Jun;45(3):429-446. doi: 10.1007/s13402-022-00675-8. Epub 2022 May 3. Cell Oncol (Dordr). 2022. PMID: 35503594
MTT, colony formation, spheroid formation and in vivo tumorigenesis assays were performed to assess the proliferation, tumorigenesis, stemness and gemcitabine (GEM) resistance of pancreatic cancer cells. Mechanistically, co-immunoprecipitation (co-IP) and chromatin …
MTT, colony formation, spheroid formation and in vivo tumorigenesis assays were performed to assess the proliferation, tumorigenesis, stemne …
DLL3 Is a Prognostic and Potentially Predictive Biomarker for Immunotherapy Linked to PD/PD-L Axis and NOTCH1 in Pancreatic Cancer.
Lacalle-Gonzalez C, Florez-Cespedes M, Sanz-Criado L, Ochieng' Otieno M, Ramos-Muñoz E, Fernandez-Aceñero MJ, Ortega-Medina L, Garcia-Foncillas J, Martinez-Useros J. Lacalle-Gonzalez C, et al. Biomedicines. 2023 Oct 17;11(10):2812. doi: 10.3390/biomedicines11102812. Biomedicines. 2023. PMID: 37893184 Free PMC article.
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive neoplasm with very poor patient survival outcomes despite available treatments. ...These facts set a rationale for testing anti-DLL3-based treatments either alone or combined with immunotherapy or other NOTCH1 …
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive neoplasm with very poor patient survival outcomes despite available treatmen …
Dexamethasone mediates pancreatic cancer progression by glucocorticoid receptor, TGFbeta and JNK/AP-1.
Liu L, Aleksandrowicz E, Schönsiegel F, Gröner D, Bauer N, Nwaeburu CC, Zhao Z, Gladkich J, Hoppe-Tichy T, Yefenof E, Hackert T, Strobel O, Herr I. Liu L, et al. Cell Death Dis. 2017 Oct 5;8(10):e3064. doi: 10.1038/cddis.2017.455. Cell Death Dis. 2017. PMID: 28981109 Free PMC article.
This was confirmed in patient and xenograft tissue, where dexamethasone induced tumor proliferation, gemcitabine resistance and metastasis. Inhibition of each TGFbeta receptor-I, glucocorticoid receptor or JNK signaling partially reversed the dexamethasone-mediated …
This was confirmed in patient and xenograft tissue, where dexamethasone induced tumor proliferation, gemcitabine resistance and metastasis. …
SHCBP1 interacting with EOGT enhances O-GlcNAcylation of NOTCH1 and promotes the development of pancreatic cancer.
Yang C, Hu JF, Zhan Q, Wang ZW, Li G, Pan JJ, Huang L, Liao CY, Huang Y, Tian YF, Shen BY, Chen JZ, Wang YD, Chen S. Yang C, et al. Genomics. 2021 Mar;113(2):827-842. doi: 10.1016/j.ygeno.2021.01.010. Epub 2021 Jan 28. Genomics. 2021. PMID: 33515675 Free article.
Pancreatic cancer cell lines and nude mouse models were used for in vitro and in vivo experiments. ...We further clarified the molecular mechanisms by which EOGT and SHCBP1 enhance the O-GlcNAcylation of NOTCH1, Subsequently promoting the nuclear localization …
Pancreatic cancer cell lines and nude mouse models were used for in vitro and in vivo experiments. ...We further clarified the …
The stromal-tumor amplifying STC1-Notch1 feedforward signal promotes the stemness of hepatocellular carcinoma.
Bai S, Zhao Y, Chen W, Peng W, Wang Y, Xiong S, Aruna, Li Y, Yang Y, Chen S, Cheng B, Wang R. Bai S, et al. J Transl Med. 2023 Mar 31;21(1):236. doi: 10.1186/s12967-023-04085-8. J Transl Med. 2023. PMID: 37004088 Free PMC article.
In HCC patients, the expression of STC1 was positively correlated with Notch1 expression and poor prognosis. The co-IP assay showed that STC1 directly bound to Notch1 receptors to activate the Notch signaling pathway, thereby promoting the stemness of HCC cells. ... …
In HCC patients, the expression of STC1 was positively correlated with Notch1 expression and poor prognosis. The co-IP assay showed t …
Oncogene APOL1 promotes proliferation and inhibits apoptosis via activating NOTCH1 signaling pathway in pancreatic cancer.
Lin J, Xu Z, Xie J, Deng X, Jiang L, Chen H, Peng C, Li H, Zhang J, Shen B. Lin J, et al. Cell Death Dis. 2021 Aug 2;12(8):760. doi: 10.1038/s41419-021-03985-1. Cell Death Dis. 2021. PMID: 34341330 Free PMC article.
Nevertheless, the role of APOL1 in the regulatory mechanisms of pancreatic cancer remains unknown and should be explored. We identified APOL1 was abnormally elevated in human pancreatic cancer tissues compared with that in adjacent tissues and was asso …
Nevertheless, the role of APOL1 in the regulatory mechanisms of pancreatic cancer remains unknown and should be explored. We i …
Significance of Notch1-signaling pathway in human pancreatic development and carcinogenesis.
Hu H, Zhou L, Awadallah A, Xin W. Hu H, et al. Appl Immunohistochem Mol Morphol. 2013 May;21(3):242-7. doi: 10.1097/PAI.0b013e3182655ab7. Appl Immunohistochem Mol Morphol. 2013. PMID: 23235341 Free PMC article.
Here we examined the expression pattern of Notch1 and Hes1 in human fetal pancreatic tissues to elucidate the role of Notch1 in human pancreatic embryonic development. ...We also showed that the expression of both Notch1 and Hes1 are present in …
Here we examined the expression pattern of Notch1 and Hes1 in human fetal pancreatic tissues to elucidate the role of Notch …
106 results